Association of cognitive function with fall-related outcomes in Thai older adults with and without mild cognitive impairment

Authors

  • Peerakan Inkhao, BSc Chula Neuroscience Center, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand
  • Phunsuk Kantha, PhD, PT Research and Innovation Center of Human Movement Sciences (RICHms), Faculty of Physical Therapy, Mahidol University, Nakhon Pathom, Thailand https://orcid.org/0000-0003-1739-9524
  • Kulvara Lapanan, MSc, PT Neuroscience Research Australia, University of New South Wales, Sydney, Australia https://orcid.org/0000-0002-5185-9638
  • Makha Phongjit, BSc Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
  • Jakkrit Amornvit, MD Chula Neuroscience Center, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand / Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand https://orcid.org/0000-0002-9278-2067

Keywords:

falling, older adults, functional performance, cognitive function

Abstract

Objective: This study aimed to investigate the relationship between cognitive function and fall-related outcomes, including fear of falling and functional performance, in older adults with and without mild cognitive impairment (MCI).

Materials and Methods: A cross-sectional study was conducted with 75 community-dwelling older adults (50 healthy older adults and 25 older adults with MCI). Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA), while fear of falling (FoF) was measured using the Falls Efficacy Scale-International (FES-I). Functional performance was evaluated using the Timed Up and Go (TUG) test and Chair Stand Test (CST). Group differences were analyzed using Mann–Whitney U tests, and linear regression models examined associations between MoCA scores and fall-related outcomes.

Results: Older adults with MCI exhibited significantly poorer functional performance than their cognitively healthy counterparts, with longer TUG durations (p = 0.009) and fewer CST repetitions (p = 0.002). Overall, regression analyses revealed a significant association between lower MoCA scores and longer TUG times (p = 0.025), as well as fewer CST repetitions (p = 0.001). However, no significant relationship was found between MoCA scores and FES-I scores (p = 0.737).

Conclusion: Cognitive function is associated with functional performance, particularly mobility and lower extremity strength, in older adults. However, FoF may be influenced by factors beyond cognitive decline, such as psychological or emotional aspects. These findings highlight the importance of integrating cognitive and physical interventions to reduce fall risk in older adults with MCI.

References

Petersen RC. Mild cognitive impairment. Continuum (Minneap Minn). 2016;22(2 Dementia):404-18.

Kitro A, Panumasvivat J, Sirikul W, Wijitraphan T, Promkutkao T, Sapbamrer R. Associations between frailty and mild cognitive impairment in older adults: evidence from rural Chiang Mai province. PLoS One. 2024;19(4):e0300264.

Okonkwo OC, Griffith HR, Vance DE, Marson DC, Ball KK, Wadley VG. Awareness of functional difficulties in mild cognitive impairment: a multidomain assessment approach. Journal of the American Geriatrics Society. 2009;57(6):978-84.

Minta K, Colombo G, Taylor WR, Schinazi VR. Differences in fall-related characteristics across cognitive disorders. Frontiers in Aging Neuroscience. 2023;15:1171306.

Simpkins C, Khalili SM, Yang F. Meta-analysis-based comparison of annual fall risk between older adults with Alzheimer’s disease and mild cognitive impairment. Advances in Geriatric Medicine and Research. 2024;6(1):e240002.

Hopkins J, Hill K, Jacques A, Burton E. Prevalence, risk factors and effectiveness of falls prevention interventions for adults living with mild cognitive impairment in the community:a systematic review and meta-analysis.Clinical Rehabilitation. 2023;37(2):215-43.

Schoene D, Heller C, Aung YN, Sieber CC, Kemmler W, Freiberger E. A systematic review on the influence of fear of falling on quality of life in older people: is there a role for falls? Clinical Interventions in Aging. 2019;14:701-19.

Ma L. Depression, anxiety, and apathy in mild cognitive impairment: current perspectives. Frontiers in Aging Neuroscience. 2020;12:9.

Carson N, Leach L, Murphy KJ. A re-examination of Montreal Cognitive Assessment (MoCA) cutoff scores. International Journal of Geriatric Psychiatry. 2018;33(2):379-88.

Tinetti ME, Richman D, Powell L. Falls efficacy as a measure of fear of falling. Journal of Gerontology. 1990;45(6):P239-P43.

Dewan N, MacDermid JC. Fall Efficacy Scale-International (FES-I). Journal of Physiotherapy. 2014;60(1):60.

Montero-Odasso M, van der Velde N, Martin FC, Petrovic M, Tan MP, Ryg J, et al. World guidelines for falls prevention and management for older adults: a global initiative. Age and Ageing. 2022;51(9):afac205.

Makizako H, Kiyama R, Nakai Y, Kawada M, Tomioka K, Taniguchi Y, et al. Reference values of chair stand test and associations of chair stand performance with cognitive function in older adults. Aging and Health Research. 2022;2(3):100090.

Price A, Stradtman M, Alber J, Durkin M. Ad-risk factors and timed up and go tasks in impaired and unimpaired older adults. Innovation in Aging. 2024;8(Supplement_1):801.

Hesterberg TC. What teachers should know about the bootstrap: resampling in the undergraduate statistics curriculum. The American Statistician. 2015;69(4):371-86.

Amboni M, Barone P, Hausdorff JM. Cognitive contributions to gait and falls: evidence and implications. Movement Disorders : official journal of the Movement Disorder Society. 2013;28(11):1520-33.

Zhao X, Huang H, Du C. Association of physical fitness with cognitive function in the community-dwelling older adults. BMC Geriatrics. 2022;22(1):868.

Maclean LM, Brown LJE, Khadra H, Astell AJ. Observing prioritization effects on cognition and gait: The effect of increased cognitive load on cognitively healthy older adults’ dual-task performance. Gait & Posture. 2017;53:139-44.

Stuhr C, Hughes CML, Stöckel T. Task-specific and variability-driven activation of cognitive control processes during motor performance. Scientific Reports. 2018;8(1):10811.

Racey M, Markle-Reid M, Fitzpatrick-Lewis D, Ali MU, Gagne H, Hunter S, et al. Fall prevention in community-dwelling adults with mild to moderate cognitive impairment: a systematic review and meta-analysis. BMC Geriatrics. 2021;21(1):689.

Iaboni A, Flint AJ. The complex interplay of depression and falls in older adults: a clinical review. The American Journal of Geriatric Psychiatry : official journal of the American Association for Geriatric Psychiatry. 2013;21(5):484-92.

Spanò B, Lombardi MG, De Tollis M, Szczepanska MA, Ricci C, Manzo A, et al. Effect of dual-task motor-cognitive training in preventing falls in vulnerable elderly cerebrovascular patients: a pilot study. Brain Sciences. 2022;12(2):168.

Downloads

Published

2025-06-12

How to Cite

1.
Inkhao P, Kantha P, Lapanan K, Phongjit M, Amornvit J. Association of cognitive function with fall-related outcomes in Thai older adults with and without mild cognitive impairment. Int. Phys. Ther. Res. Symp. 11th [Internet]. 2025 Jun. 12 [cited 2025 Jul. 11];11(1):233-45. Available from: https://conference.in.th/index.php/IPTRS2025/article/view/Inkhao_et_al.2025