The comparison of pulmonary function and exercise capacity between non-anemia and anemia chronic obstructive pulmonary disease (COPD)
Keywords:
anemia, COPD, pulmonary function test, six-minute walk distance (6MWD)Abstract
Objective: The purpose of this study is to compare pulmonary function test (PFT) and exercise capacity between non-anemia and anemia COPD patients.
Materials and Methods: A total of 80 participants with COPD were enrolled and divided into non-anemic and anemic COPD. Pulmonary function test was assessed using standard spirometry to measure forced vital capacity (FVC), forced expiratory volume in one second (FEV₁), and the FEV₁/FVC ratio. Exercise capacity was evaluated using the six-minute walk test (6MWT), with the six-minute walk distance (6MWD) recorded and adjusted for each participant.
Results: The results shown FVC and the %predicted FVC were statistically significant differences between anemic and non-anemic COPD. The FEV1, % predicted FEV1, and FEV1/FVC were no statistically significant differences between anemic and non-anemic COPD. Additionally, 6MWD was significantly lower in anemic COPD compared to non-anemia COPD (p < 0.05), suggesting that anemia is associated with reduced exercise capacity in COPD patients.
Conclusions: Anemic COPD patients had significantly lower FVC, %predicted FVC, and 6MWD (p < 0.05), indicating impaired pulmonary function and exercise capacity. Hemoglobin level may be a useful parameter for assessing rehabilitation readiness and guiding treatment decisions in this group.
References
Global Initiative for Chronic Obstructive Lung Disease. Global Strategy for Prevention, Diagnosis and Management of COPD: 2024 report. 2024; 1-49.
Aaron SD, Tan WC, Bourbeau J, Sin DD, Loves RH, MacNeil J,. et al. Global Initiative for Chronic Obstructive Lung Disease 2017 Classification and Lung Function Decline in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2018; 197(5): 670-673.
Wouters EF, Creutzberg EC, Schols AM. Systemic effects in COPD. Chest. 2002; 121(5 Suppl): 127S-130S.
Agusti AG, Noguera A, Sauleda J, Sala E, Pons J, Busquets X. Systemic effects of chronic obstructive pulmonary disease. Eur Respir J. 2003; 21(2): 347-360.
Decramer M, De Benedetto F, Del Ponte A, Marinari S. Systemic effects of COPD. Respir Med. 2005; 99 Suppl B:S3-10.
John M, Lange A, Hoernig S, Witt C, Anker SD. Prevalence of anemia in chronic obstructive pulmonary disease: comparison to other chronic diseases. Int J Cardiol. 2006; 111(3): 365-370.
Beauchamp MK. Balance assessment in people with COPD: An evidence-based guide. Chron Respir Dis. 2019;16:1479973118820311.
Similowski T, Agusti A, MacNee W, Schonhofer B. The potential impact of anaemia of chronic disease in COPD. Eur Respir J. 2006; 27(2): 390-396.
ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med. 2002; 166(1): 111-117.
Honeyman P, Barr P, Stubbing DG. Effect of a walking aid on disability, oxygenation, and breathlessness in patients with chronic airflow limitation. J Cardiopulm Rehabil. 1996; 16(1): 63-67.
Roul G, Germain P, Bareiss P. Does the 6-minute walk test predict the prognosis in patients with NYHA class II or III chronic heart failure? Am Heart J. 1998; 136(3): 449-457.
Cote C, Zilberberg MD, Mody SH, Dordelly LJ, Celli B. Haemoglobin level and its clinical impact in a cohort of patients with COPD. Eur Respir J. 2007; 29:923-9.Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et.al. Standardisation of spirometry. Eur Respir J. 2005; 26(2): 319-3.
Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et.al. Standardisation of spirometry. Eur Respir J. 2005; 26(2): 319-3.
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